Curation and annotation
We aim to provide comprehensive coverage of large-scale RNAi screening data in the literature. Priority is given to data of high scientific impact. Due to limited capacities, we currently focus on data from Homo sapiens and Drosophila melanogaster.
Annotation guidelines are essential for conclusive comparisons across various datasets based on the application of different assay types. We defined controlled vocabularies and postulated vocabulary guidelines for each database field, in order to ensure a comparable description of experimental and phenotypic data within the GenomeRNAi database.
Update of pre-existing data
Some of the screening data in the database still need to be updated to the current annotation standard (pre-existing data, having GenomeRNAi IDs ending on ‘-A-0’). Application of the new annotation guidelines to these data is ongoing