Our group has long-standing experience in cell-based RNAi screening in Drosophila. We constantly develop and optimize screening reagents and methods. We developed and generated a novel genome-wide Drosophila RNAi library with an optimized design. Several genome-wide RNAi screens have been conducted so far using the second-generation library (Heidelberg 2). This library recently served to generate a genome-wide in vivo RNAi Drosophila library (VDRC KK library), enabling to perform cell-based and in vivo studies using the same RNAi constructs. The library is constantly updated according to new gene annotations and further developed in terms of specificity and efficiency.
Heidelberg 1 (HFA)
Heidelberg 2 (BKN)
- Genome-wide library
- Kinase library containing three amplicons against all kinases in the Drosophila genome
- Phosphatase library
- Transcription factor library
- C. elegans negative control library
Enquiries about RNAi reagents
The second-generation Drosophila dsRNA library (Heidelberg 2) can be obtained from us in a pre-aliquoted ready-to-use form. We provide whole-genome RNAi libraries, sub-libraries or custom-made sets for selected targets. Please contact us for costs and further information.