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Publications based on RNAi screens

Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M, Niehrs C. (2010). Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327:459-63.

Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Muller A, Boutros M, Dooley S, Hentze MW, Muckenthaler MU. (2009). SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 2009 Epub

Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C. (2009). Cell cycle control of wnt receptor activation. Dev Cell 17:788-99.

Simons, M., Gault, W.J., Gotthardt, D., Rohatgi, R., Klein, T.J., Shao, Y., Lee, H.J., Wu, A.L., Fang, Y., Satlin, L.M., Dow, J.T., Chen, J., Zheng, J., Boutros, M., Mlodzik, M. (2009). Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol., 11:286-94

Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM. (2008). Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol. 9:97-104.

Eulalio, A., Rehwinkel J., Stricker, M., Huntzinger, E., Yang, S.F., Doerks, T., Dorner, S., Bork, P., Boutros M. and Izaurralde, E. (2007). Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev., 21:2558-2570

Bartscherer K, Pelte N, Ingelfinger D, Boutros M. (2006). Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125:523-33.

Gesellchen V, Kuttenkeuler D, Steckel M, Pelte N, Boutros M. (2005). An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Rep. 6:979-84.

Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP, Boutros M. (2005). Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436:871-5.

Boutros M, Kiger AA, Armknecht S, Kerr K, Hild M, Koch B, Haas SA, Paro R, Perrimon N; Heidelberg Fly Array Consortium. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303:832-5.


Horn, T., Z. Arziman, J. Berger, and M. Boutros. (2007). GenomeRNAi: a database for cell-based RNAi phenotypes. Nucl Acid Res, D492-7.

Boutros, M., L. Bras, W. Huber. (2006). Analysis of cell-based RNAi screens. Genome Biology, R66.

Arziman, Z., T. Horn, M. Boutros. (2005). E-RNAi: A web application to design optimized RNAi constructs. Nucleic Acids Res., 33:W582-88.

Reviews and Methods

Armknecht S, Boutros M, Kiger A, Nybakken K, Mathey-Prévôt B, Perrimon N. (2005). High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol. 392:55-73.

Boutros M, Ahringer J. (2008). The art and design of genetic screens: RNA interference. Nat Rev Genet. 9:554-66.

Fuchs F, Boutros M. (2006). Cellular phenotyping by RNAi. Brief Funct Genomic Proteomic. 5:52-6.

Steinbrink S, Boutros M. (2008). RNAi screening in cultured Drosophila cells. Methods Mol Biol. 420:139-53.

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